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These data raise the possibility that CAR T cells may execute antitumor activity through 2 complementary mechanisms, (a) immediate killing of malignant cells via the release of cytotoxic factors following engagement of CD19 and (b) initiation of a local immune response, which amplifies and sustains the antitumor activity, leading to complete tumor resolution in a subset of patients

Role of ginsenoside Rg1 as a PPAR- activator in protecting against manganese-induced hepatotoxicity: insights into the TLR4/MyD88/MAPK signaling pathway